6-in-1 pest protection for every cat, every lifestyle, every month.
Because NOTHING should come between you and your cat

REV UP Protection Indoors and Out
REVOLUTION PLUS broadens the scope of protection for cats and kittens, inside and out, against fleas, ticks, ear mites, roundworms, hookworms, and heartworms.
Building on the Trusted Legacy of REVOLUTION® (selamectin)




- Safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or greater
- Simple-to-apply, quick-drying, small-volume, monthly topical solution
- One dose protects against 6 common parasites
- Helps protect the special bond between you and your cat; no separation required after applying
Parasites are NOT “outdoor-only”
Cats and kittens of every lifestyle—whether indoor-only, indoor/outdoor, or outdoor-only—can regularly come in contact with harmful pests.
Fleas, ticks, ear mites, intestinal worms, and heartworms can get into any home. Parasites hitchhike indoors on other pets or creatures, on shoes and clothes, or get inside through doors and windows.2
With ONE monthly dose, REVOLUTION PLUS protects indoor and outdoor cats against 6 common feline pests.
That’s the 6-in-1 DIFFERENCE!
REVOLUTION PLUS is an FDA-approved product that combines two active ingredients for the broadest protection against parasites
- Delivers the proven broad-spectrum protection of selamectin with the advanced flea- and tick-killing power of sarolaner
- Provides UNIQUE DUAL ACTION against fleas and ear mites


1. Fleas
In TWO clinical studies,
One dose of REVOLUTION PLUS killed 100% of adult fleas for a full 5 weeks
In a separate study,
REVOLUTION PLUS started killing fleas within 6 hours of re-infestations
- Interrupts the flea life cycle by killing fleas before they can lay eggs
- By eliminating fleas, REVOLUTION PLUS reduced signs of flea allergy dermatitis in cats
Fleas can sneak into your house and raise a family in your carpets.
Warning: This is really gross!
Why should I care about fleas?
- Fleas can hitchhike indoors on your cat, other pets or creatures, on shoes and clothes, or get inside through doors and windows
- Flea bites can cause intense itching and allergies3
- The scratching can lead to hair loss and uncomfortable skin irritations3
- Flea bites can cause anemia, especially in young kittens4
- Cats may develop behavioral problems from the anxiety of flea infestations5
- Fleas can infect cats with tapeworms3
- Getting rid of fleas can be frustrating, costly, and time-consuming
- Just 1 female flea can lay as many as 40 to 50 eggs a day and over 2000 eggs in her lifetime!4
- It’s easier and quicker to prevent an infestation than get rid of one—which can take months!
2. Ticks
REVOLUTION PLUS kills 3 types of ticks for a full month after one dose6,7



Effective results sustained for up to 5 weeks for black-legged or deer tick and American dog tick6,8
Ticks are more than a mere menace!
Ticks can hitchhike indoors on your cat, other pets or creatures, and on shoes and clothes. They are tiny and can be tough to spot. Ticks can be found anywhere in the United States—any time of year in both rural and urban environments.9
Discover the types of ticks in your area10:



Black-legged or deer tick:
Widely seen across the eastern United States.
Gulf Coast tick:
Distributed in costal areas of the US along the Atlantic coast and the Gulf of Mexico
American dog tick:
Widely distributed east of the Rocky Mountains. Also, occurs in limited areas on the Pacific Coast.
Black-legged or Deer tick
Gulf Coast tick
American dog tick
Why should I care about ticks?
- Ticks can spread several diseases in cats9,11
- They can cause skin irritation and allergic reactions9,11
3. Ear Mites
In a clinical study,
REVOLUTION PLUS killed over 99% of ear mites for a full month after one dose
Ear mites: They can be so “earitating.”
Could these critters be on your cat? Yuck!

Ear mites are passed easily between pets and stay in and around cats’ ears, feeding off debris in the ear canal.12
Why should I care about ear mites?
These “hitchhikers” can invade your home on other pets and cause severe irritation,12 including:
- Red, itchy, painful ears12
- Dark brown discharge in the ears12
- Inflamed ears that could lead to rash or other skin reactions12
- Damage to the ears caused by excessive scratching12
- Transmission to other cats and pets through direct contact12
4. Roundworms
In a clinical study,
REVOLUTION PLUS reduced nearly 100% of roundworm eggs after a single dose13
Roundworm (Toxocara cati) emerging from egg

Photo: Centers for Disease Control and Prevention
Don’t Let Roundworms Dig In
- Roundworms are the most common internal pest found in cats14
- They make themselves at home in the small intestine, then both adults and eggs are passed in a cat’s feces15
- Roundworms get into your home—and into your cat— through contaminated soil, the dirt on your shoes, or infected prey like rodents or bugs14,15
Why should I care about roundworms?
- Major roundworm infections in cats can cause vomiting, weight loss, hair changes and a potbellied appearance.14,15
5. Hookworms
In a clinical study,
REVOLUTION PLUS reduced over 99% of hookworm eggs after a single dose13
Hookworm (Ancylostoma tubaeforme)

Photo: Centers for Disease Control and Prevention
Don’t Let Them Get Their Hooks Into Your Cat
- Hookworms attach to the lining of a cat’s intestinal wall, feed on a cat’s blood, and pass eggs in a cat’s feces14
- Hookworms can invade cats whether indoors or out
- Hookworm larvae can live in soil and infect your cat through ingestion or penetration of the skin14,16
Why should I care about hookworms?
- Hookworms can cause anemia, weight loss, and diarrhea in infected cats16
- Severe hookworm infections can be fatal, especially in kittens16
6. Heartworms
In TWO clinical studies,
REVOLUTION PLUS was 100% effective in preventing heartworm disease
At least 1 in 4 cats with heartworm disease were classified as indoor-only17
Heartworms are cold-hearted pests
- Just 1 bite from an infected mosquito can give your cat heartworms18
- Indoor-only cats are at risk since it’s hard to completely mosquito proof your home18
- In one study, more than 25% of cats diagnosed with heartworms were considered indoor-only17
Why should I care about heartworms?
- Heartworm disease in cats isn’t just serious—it can be fatal17,18
- Even when it isn’t deadly, heartworm infection in cats can cause permanent lung damage known as heartworm-associated respiratory disease (HARD)18,19
The HARD facts17

Upgrade to REVOLUTION PLUS for 6-in-1 protection
REVOLUTION PLUS builds upon the proven 5-in-1 protection of REVOLUTION®, veterinarians’
#1 trusted pest treatment for cats—PLUS it now protects against ticks, too.1,20





How does REVOLUTION PLUS compare to other treatments?
Compare the labels of other products with REVOLUTION PLUS by swiping left or right.


*REVOLUTION PLUS is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects against fleas (Ctenocephalides felis), ticks (black-legged or deer tick, (Ixodes scapularis), Gulf Coast tick (Amblyomma maculatum) and American dog tick (Dermacentor variabilis)), ear mites (Otodectes cynotis), roundworms (Toxocara cati), hookworms (Ancylostoma tubaeforme), and heartworms (Dirofilaria immitis) for cats and kittens as young as eight weeks of age and weighing 2.8 pounds or greater.
†REVOLUTION PLUS provides UNIQUE DUAL ACTION against fleas and ear mites
‡Advantage Multi is indicated for the treatment of flea infestations, as well as the treatment and control of ear mite infestations and intestinal parasite infections.
§Frontline Gold is indicated for adult fleas, flea larvae, flea eggs, and 4 common species of ticks.
IIBravecto is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of Ixodes scapularis (black-legged tick) infestations.
¶Bravecto failed to demonstrate ≥90% effectiveness against Dermacentor variabilis beyond 8 weeks.
#Heartworms are transmitted by mosquitoes.
**Do not use on sick, debilitated, or underweight cats.
††Use with caution in cats with a history of neurologic abnormalities. Neurologic abnormalities have been reported in cats receiving Bravecto, even in cats without a history of neurologic abnormalities. Do not contact or allow children to contact the application site until dry. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product.
Advantage Multi® is a registered trademark of Bayer. Bravecto® is a registered trademark of Merck Animal Health. Frontline® Gold is a registered trademark of Merial.